1. Rectal administration of artemisinin antimalarials generally effective--a meta-analysis
(Journal Club/Malaria)

...s of artemisinin derivatives differ in their pharmacokinetic disposition. Most available evidence pertains to artesunate and artemisinin. Despite marked interindividual variability in bioavailability,...

2. Dihydroartemisinin-piperaquine compares well with artesunate-mefloquine for malaria and is cheaper
(Journal Club/Malaria)

...combinations:  three days of eaither dihydroartemisinin-piperaquine or the more standard but more costly artesunate-mefloquine "Interpretation: Dihydroartemisinin-piperaquine is a highly e...

3. Seasonal IPT of malaria in Senegalese children: large RCT
(Journal Club/Malaria)

This study randomized 1136 children aged 2–59 months to receive either one dose of artesunate plus one dose of sulfadoxine-pyrimethamine or two placebos on three occasions during the malaria tra

4. Artesunate plus sulfadoxine-pyrimethamine in Sudan
(Journal Club/Latest Articles)

Though there are many studies of various drug combinations for malaria, relatively few have looked at artesunate plus sulfadoxine-pyrimethamine even though it is often used. This study conducted in 20

5. Artesunate-amodiaquine works in Nigeria, too
(Journal Club/Latest Articles)

It is not really news that  artesunate-amodiaquine (AA) is an effective treatment for malaria, with fewer failures than chloroquine +  pyrimethamine-sulfadoxine (CQ-SP), but a newly reported

6. 5-Day Nonobserved Artesunate for Uncomplicated Malaria in Gabonese Children
(Journal Club/Malaria)

A 5-day course of oral artesunate monotherapy (first day: 4 mg/kg body weight, observed intake; and 2 mg/kg body weight on the following days with nonobserved drug intake) yielded a PCR-corrected Day

7. Artesunate-Amodiaquine vs Artemether-Lumefantrine for Uncomplicated Childhood Malaria in Tanzania
(Journal Club/Malaria)

Efficacy of Artesunate Plus Amodiaquine versus That of Artemether-Lumefantrine for the Treatment of Uncomplicated Childhood Plasmodium falciparum Malaria in Zanzibar, Tanzania.  Both treatments w

8. Artesunate-Clindamycin versus Quinine-Clindamycin in the Treatment of Plasmodium falciparum Malaria
(Journal Club/Malaria)

Clin Infect Dis. 2005 Jun 15;40(12):1777-84. Epub 2005 May 3 Open-label RCT evaluating oral artesunate-clindamycin vs quinine-clindamycin, both given twice daily for 3 days, for the treatment of u

9. Artesunate versus quinine for treatment of severe falciparum malaria (Lancet)
(Journal Club/Malaria)

The Lancet 2005; 366:717-725 DOI:10.1016/S0140-6736(05)67176-0 Open label RCT of IV artesunate vs quinine for severe malaria in three south Asian countries. Mortality in artesunate recipient