1. A protective antibody against falciparum malaria
(Journal Club/Malaria)

...rt the further development of MSP3-based vaccine formulations." Long-Term Clinical Protection from Falciparum Malaria Is Strongly Associated with IgG3 Antibodies to Merozoite Surface Prote...

2. Comparison of rapid tests for malaria in Madagascar: CareStart found most sensitive
(Journal Club/Malaria)

...; test, and 92.6% for the OptiMAL-IT™ test. All the tests were less sensitive to non-falciparum infections and in patients with parasite loads of less than 500 parasites/&micr...

3. NOW® malaria rapid test performs well -- it least in Italy
(Journal Club/Malaria)

... "Although the NOW Malaria rapid test was both sensitive (100%) and specific (100%) in detecting P. falciparum infections, it was less specific (93.1%) and sensitive (90.7%) in identifying t...

4. NEJM Case 32-2006 — A 3-year-old girl with fever after a visit to Africa
(Journal Club/Travel Medicine)

Case 32-2006 — A 3-Year-Old Girl with Fever after a Visit to Africa. NEJM 355:1715-1722

5. Amodiaquine with or without SP safe, more effective than chloroquine in pregnancy
(Journal Club/Ob/Gyn)

Randomized trial involving 900 pregnant women in Ghana with P. falciparum treated with chloroquine, sulfadoxine-pyramethamine (SP), amodiaquine, or amodiaquine + SP. "PCR-corrected parasi

6. Monthly SP superior to 2-dose regimen for prevention of malaria in HIV-infected women
(Journal Club/Ob/Gyn)

...ce of its decreasing efficacy for the treatment of malaria in children. In areas with intense transmission of falciparum malaria and a high prevalence of HIV infection, monthly SP IPTp should be adopt...

7. Dihydroartemisinin-piperaquine compares well with artesunate-mefloquine for malaria and is cheaper
(Journal Club/Malaria)

...tion: Dihydroartemisinin-piperaquine is a highly efficacious and inexpensive treatment of multidrug-resistant falciparum malaria and is well tolerated by all age groups. The effectiveness of the unsup...

8. Infection with multiple strains of P falciparum associated with treatment failures
(Journal Club/Malaria)

Did you know that African patients with malaria are often infected by multiple strains of P. falciparum? I didn't. This study looked at the response to three different combination treatments in relati

9. Cotrimoxazole prophylaxis not found to increase malaria resistance to SP
(Journal Club/Malaria)

...dy high resistance to SP. Mahamadou A. Thera et al., Impact of Trimethoprim-Sulfamethoxazole Prophylaxis on Falciparum Malaria Infection and Disease, J Infect Dis 192:1823-1829 Nov 15, 2005. Free ac...

10. Artesunate plus sulfadoxine-pyrimethamine in Sudan
(Journal Club/Latest Articles)

...and safe.Elamin S. et al. Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan. Malaria Journal 2005, 4:41, doi:10.1186/1475-2875-4-41...

11. Malaria methylene blues
(Journal Club/Latest Articles)

...ner P et al. Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso. Malaria Journal 2005, 4:45, doi...

12. Artesunate-amodiaquine works in Nigeria, too
(Journal Club/Latest Articles)

...rtesunate-amodiaquine vs. chloroquine-pyrimethamine-sulfadoxine for the treatment of uncomplicated Plasmodium falciparum malaria in Nigerian children. Trop Med Intl Health 10 (11):1161-1170, doi: 10.1...

13. Intermittent preventive antimalarial treatment for Tanzanian infants: follow-up to age 2 years of a randomised, placebo-controlled trial
(Journal Club/Latest Articles)

...rebound effect and suggesting that such treatment could facilitate development of immunity against Plasmodium falciparum." Schellenberg D et al. The Lancet 2005; 365:1481-1483."Stopping anti...

14. Parasitological Rebound Effect and Emergence of Pyrimethamine Resistance in Plasmodium falciparum after Single-Dose Sulfadoxine-Pyrimethamine
(Journal Club/Latest Articles)

...drug resistance. Here, the effect of single-dose sulfadoxine-pyrimethamine (S-P) versus placebo on Plasmodium falciparum infection rates was assessed in 63 selected infants who were aparasitemic at en...

15. Artemisinin-based combinations (Review)
(Journal Club/Latest Articles)

...ne, a newer fixed combination, was a highly efficacious and well tolerated treatment for multi-drug resistant falciparum malaria in Southeast Asia. SUMMARY: Early diagnosis and treatment of uncomplica...

16. Amodiaquine, sulfadoxine-pyrimethamine, and combination therapy for uncomplicated falciparum malaria in Burkina Faso
(Journal Club/Malaria)

...aquine (AQ), sulfadoxine-pyrimethamine (SP) and both together (AQ+SP) in 944 patients with uncomplicated falciparum malaria in Burkina Faso. Half the patients were under 5 years old. The AQ+...

17. Malaria Research in Africa - Multilateral Initiative on Malaria
(Journal Club/Malaria)

...tirely on malaria. Interesting looking articles include: Rapid increase in resistance of Plasmodium falciparum to chloroquine-Fansidar in Uganda and the potential of amodiaquine-Fansidar as ...

18. SP & Amodiaquine in Children With Malaria in Tanzania
(Journal Club/Malaria)

... Therapeutic Efficacy Of Sulfadoxine-Pyrimethamine And Amodiaquine in Children With Uncomplicated Plasmodium Falciparum Malaria In Zanzibar, Tanzania....

19. 5-Day Nonobserved Artesunate for Uncomplicated Malaria in Gabonese Children
(Journal Club/Malaria)

... 73(4), 2005, pp. 705-709. Full Title: 5-Day Nonobserved Artesunate Monotherapy For Treating Uncomplicated Falciparum Malaria In Young Gabonese Children. We regularly use Fansidar (sulfadoxine...

20. Travel medicine and malaria—a review of the current issues
(Journal Club/Malaria)

... to the topic of malaria and includes these articles: The role of standby emergency medication for falciparum malaria: current opinion Malaria and the pregnant traveller Malaria s...