Open-label RCT evaluating oral artesunate-clindamycin vs quinine-clindamycin, both given twice daily for 3 days, for the treatment of uncomplicated falciparum malaria in 100 Gabonese children. The activity of artesunate-clindamycin was comparable to that of quinine-clindamycin in the cure rates at day 28 of follow-up.
The Lancet 2005; 366:717-725 DOI:10.1016/S0140-6736(05)67176-0
Open label RCT of IV artesunate vs quinine for severe malaria in three south Asian countries. Mortality in artesunate recipients was 15% (107 of 730) compared with 22% (164 of 731) in quinine recipients. Treatment with artesunate was well tolerated, whereas quinine was associated with hypoglycaemia.
(This article is also reviewed in Evidence Based Medicine, 2006;11:52; doi:10.1136/ebm.11.2.52)
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