ECWA Evangel Hospital, Jos, Nigeria - Haloperidol plus promethazine better than haloperidol alone for rapid tranquilization

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Haloperidol plus promethazine better than haloperidol alone for rapid tranquilization

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published 24-10-2007

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"Results Primary outcome data were available for 311 (98.4%) people, 77% of whom were thought to have a psychotic illness. Patients allocated haloperidol plus promethazine were more likely to be tranquil or asleep by 20 minutes than those who received intramuscular haloperidol alone (relative risk 1.30, 95% confidence interval 1.10 to 1.55; number needed to treat 6, 95% confidence interval 4 to 16; P=0.002). No differences were found after 20 minutes. However, 10 cases of acute dystonia occurred, all in the haloperidol alone group. "

Rapid tranquillisation in psychiatric emergency settings in Brazil: pragmatic randomised controlled trial of intramuscular haloperidol versus intramuscular haloperidol plus promethazine. BMJ, doi:10.1136/bmj.39339.448819.AE (published 22 October 2007)

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Good for journal club

By: Mike Blyth (Registered) published 24-10-2007

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Good for journal club

By: Mike Blyth (Registered IP 196.47.91.146) published 24-10-2007

This might be good for journal club. Simple, with a practical application. Could also be duplicated fairly easily in an African hospital.

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